Hypersensitivity to fluoroquinolones; Children up to age 18 years, pregnancy, lactation; patients with deficiency of glucose-6-phosphate dehydrogenase; patients with epilepsy (including history), lower seizure threshold (including after head trauma, stroke or inflammation in the central nervous system); if there are indications of defeat tendons on the background of the earlier receiving fluoroquinolones.
Severe sustanon 350 cerebral atherosclerosis, cerebral circulatory disorders, including a history of other organic lesion of the central nervous system, chronic renal failure, prolongation of the interval QT.
Dosing and Administration
Doses are selected individually depending on the location and severity of the infection and the sensitivity of the microorganisms and the general status of the patient
in patients with normal renal function sredneterapevticheskih single dose is 200 mg, administered twice daily at an interval of 12 hours. While improving the condition of the patient is transferred to oral administration of the same daily dose.
For the treatment of serious infections, including patients with impaired immune status, a single dose may be increased to 400 mg, administered in / in the drip 2 times a day.
in patients with impaired renal function first, loading dose, the same as in patients with normal renal function and depends on the location and severity of the infection.
From the digestive system : nausea, vomiting, diarrhea, flatulence, abdominal pain, increased activity of “liver” transaminases, hyperbilirubinemia, cholestatic jaundice, loss of appetite, pseudomembranous enterocolitis. From the nervous system and sensory organs senses : headache, dizziness, lack of movement, tremors, convulsions, numbness and paresthesias of extremities, “nightmarish” dream, psychotic reactions, anxiety, state of arousal, phobias, depression, confusion, hallucinations, sustanon 350 increased intracranial pressure; violation of color vision, diplopia, disturbances of taste, smell, hearing and balance. From the musculoskeletal system : tendinitis, myalgia, arthralgia, tendon rupture. On the part of the cardiovascular system : hypotension, collapse (with a sharp decrease in blood pressure introduction is stopped) , tachycardia, arrhythmia (a risk factor – hypokalemia, disease and taking medications that contribute to lengthening of the QT interval). allergic reactions : skin rash, pruritus, urticaria, hypersensitivity pneumonitis, allergic nephritis, eosinophilia, fever, angioedema, bronchoconstriction; erythema multiforme exudative (including Stevens-Johnson syndrome) and toxic epidermal necrolysis (Lyell’s syndrome), photosensitivity, vasculitis, bullous hemorrhagic dermatitis, anaphylactic shock. On the part of the blood system and organs of hematopoiesis : leukopenia, agranulocytosis, anemia, thrombocytopenia, pancytopenia, hemolytic and aplastic anemia. From the urinary system : acute interstitial nephritis, renal dysfunction, hypercreatininemia, increasing concentrations of urea. Local reactions : pain, redness at the site / in the introduction, thrombophlebitis. Other : intestinal dysbiosis, superinfection, hyper- or hypoglycemia (in patients with diabetes mellitus in patients receiving antidiabetic drugs), exacerbation of porphyria, vaginitis.
Overdosing Symptoms : dizziness, confusion, lethargy, disorientation, seizures, drowsiness, vomiting, mucosal irritation symptoms. Treatment : forced diuresis, symptomatic therapy; for the relief of neurological disorders (convulsions) used diazepam.
Interaction with other medicinal products
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Co-administration Ofloksabola ® and barbiturates can lead to a sharp decrease in blood pressure. Therefore, while using the barbiturates, for example, as agents for anesthesia and should monitor the function of the cardiovascular system.
Theophylline, fenbufen, other non-steroidal anti-inflammatory drugs: their simultaneous reception . Can lower the threshold for seizure activity
practically does not affect the concentration of theophylline in serum.
Probenecid, cimetidine, furosemide, methotrexate reduced tubular secretion that while taking leads to increased serum levels of antibiotic, increasing the probability of adverse drug reactions.
vitamin K antagonists: simultaneous reception sustanon 350 leads to increased activity of coumarin derivatives, which requires monitoring of indicators of blood coagulation.
Glibenclamide: while admission to may experience a slight increase in the level of glucose-lowering medications and, as a consequence, hypoglycemia, which requires monitoring of blood glucose.
when concomitant administration with corticosteroids increases the risk of tendon rupture, particularly in elderly patients.
in the appointment of drugs alkalizing the urine (carbonic anhydrase inhibitors, citrate, sodium bicarbonate), increases the risk of crystalluria and nephrotoxic effects.
Should not be mixed with heparin due to the risk of precipitation in solution. buy legal anabolic steroids online
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