Should be swallowed whole with a little liquid, taken with or without food, it can not chew or crush, should be protected from moisture and remove the foil directly in front of the reception.
The starting dose is 30 mg 1 time per day. Further dose may remain equal to 1 30 mg once a day or may be gradually increased to 60 mg once a day 1, and even up to 1 120 mg once a day depending on the severity of the disease and individual patient response. Duration of treatment is determined by the doctor.
With the incidence of ≥ 0.01% and <0.1% of patients Common symptoms: allergic reaction (swelling of the tongue, lower blood pressure, tachycardia, fever), chills, chest pain. Cardiovascular System:angina, nosebleeds Digestive system: anorexia , belching, gingivitis, gingival hyperplasia, increased activity of gamma glutamataminotranspeptidazy and sustanon 250 side effects transaminases (aspartate aminotransferase and alanine aminotransferase), vomiting. Musculoskeletal system: arthralgia, myalgia. Central nervous system: gipostezii tremor. Skin: angioedema, maculopapular, pustular, vesiculobullous rash, urticaria. The autonomic nervous system: increased sweating. sensory organs: impaired vision (diplopia, amblyopia), pain in the eyeballs. urinary system: dysuria, frequent urination, worsening renal function in patients with renal insufficiency.
With a frequency of <0.01% of patients Common symptoms include anaphylactic reactions. Digestive system: bezoar (lumps in the stomach from undigested food residue), dysphagia, esophagitis, intestinal obstruction, intestinal ulcers, jaundice. Hemopoiesis system: a leukopenia. Skin: exfoliative . dermatitis, photosensitive dermatitis, purpura Endocrine system: . gynecomastia, hyperglycemia, weight losssenses: . blurred vision When receiving nifedipine occur as side effects such as: asymptomatic agranulocytosis, thrombocytopenia, development or exacerbation of congestive heart failure, rarely – pulmonary edema (shortness of breath, cough, or stridor), transient loss of vision, swelling of the joints.
Symptoms: loss of consciousness up to coma, marked reduction of blood pressure, tachycardia / bradycardia, hyperglycemia, metabolic acidosis, hypoxia, cardiogenic shock, accompanied by pulmonary edema.
for emergency assistance activities with an overdose should primarily be aimed at elimination of nifedipine from the body and restoration of stable hemodynamics. Recommended gastric lavage and irrigation as necessary to prevent the intestinal absorption of the drug further. Hemodialysis is impractical, as nifedipine is not displayed during dialysis; recommended the appointment of plasmapheresis (for nifedipine characterized by a high degree of binding to plasma proteins and a relatively small volume of distribution).
If bradycardia – β-sympathomimetics, with life-threatening bradycardia – implantation of a temporary pacemaker. In marked decrease in blood pressure is recommended that a slow intravenous injection of 10-20 ml of 10% calcium gluconate solution (permissible re-introduction), which with the ineffectiveness of the appointment of sympathomimetic vasoconstrictor dopamine or norepinephrine. The doses of these drugs are selected depending on the resulting therapeutic effect.
The introduction of the liquid to be limited due to the risk of heart overload.
INTERACTION WITH OTHER DRUGS
hypotensive effect of nifedipine may increase while the use of drugs to lower blood pressure, as well as sustanon 250 side effects inhalation anesthetics, prazosin and other alpha-blocker.
The hypotensive effect of reducing sympathomimetic, non-steroidal anti-inflammatory drugs (NSAIDs) because prostaglandins synthesis suppression in kidney and delay sodium and fluids in the body, estrogens (fluid retention), and calcium preparations.
Nifedipine is metabolized by the enzyme cytochrome P450 3A4, therefore, drugs that inhibit or induce these enzymes may interact with nifedipine at its ingestion, breaking clearance or the effect of “first pass” through the liver. anabolic steroids online buy stanozolol online where can i buy anabolic steroids online