Sodium Alendronate is a bisphosphonate, a synthetic analog of pyrophosphate binding hydroxyapatite bone.As a non-hormonal specific inhibitor of osteoclast activity, inhibits bone resorption. No effect on the formation of bone tissue. It stimulates bone formation sustanon 250 reviews and restores a positive balance between bone resorption and bone reconstruction. Progressive increases bone mineral density (regulates calcium and phosphorus metabolism), promotes the formation of bone tissue of normal composition and structure.
Absorbability after a single receiving 35 or 70 mg in the morning on an empty stomach 2 hours before breakfast is 0.64%. When a shortened interval between taking the drug and food: 0,46-0,39%. This decrease absorbability has no significant impact on the effectiveness of the drug. Simultaneous treatment with coffee or orange juice reduced bioavailability by 60%. Distribution : after oral administration is temporarily distributed in soft tissue, then quickly integrated into the bone tissue. Connection with the plasma protein ~ 78%. Metabolism : data confirming alendronate metabolism in the human body, no.Excretion : Absorbed but not embedded in the bone alendronate is rapidly excreted by the kidneys. Saturating maximum capacity of bone in animals could not be established by intravenous administration the daily cumulative dose of 35 mg / kg. Despite the lack of evidence for kidney excretion of alendronate probably decrease with increasing accumulation in the bone tissue.
Treatment of osteoporosis in postmenopausal women (reducing the risk of fractures of the spinal vertebrae and hip bones of the head). Treatment of osteoporosis in men (a decrease fracture risk of the spinal vertebrae and pelvis).
hypersensitivity to any component of the drug; anomalies of the esophagus and other factors complicating esophageal patency (achalasia, strictures, etc.); the inability of the patient to remain in an upright position, sitting at least for 30 minutes; hypocalcemia, chronic renal insufficiency (creatinine clearance <35 mL / min), pregnancy, lactation, infancy, deficiency of vitamin D, severe disorders of mineral metabolism. Precautions : digestive tract disease in the acute phase (dysphagia, oesophageal disease, gastritis, duodenitis , ulcers, serious gastrointestinal disease in the previous 12 months, for example, peptic ulcer, gastrointestinal bleeding, surgical intervention, with the exception of operations on spastic pylorus).
Pregnancy and lactation Pregnancy : due to the lack of necessary clinical experience with alendronate during pregnancy is contraindicated. Breastfeeding period : the penetration of data in breast milk is not; receiving alendronate sustanon 250 reviews during lactation is contraindicated.
DOSAGE AND ADMINISTRATION
The recommended dose is 70 mg once a week. For optimal absorbability of the drug should be taken on an empty stomach in the morning, 2 hours (at least 30 minutes) before the first meal or liquid, drank plain drinking water. Other drinks, including mineral water, food, a number of drugs may impair the absorption of alendronate.
To avoid local irritation of the mucous membrane of the oral cavity and esophagus in the morning, immediately after getting up from the bed should drink at least 200 ml of water, then take a pill, not razzhёvyvaya and without letting it dissolve in the mouth, over the next 30 minutes, you can not take the horizontal position of the body, on the expiry of this period should take breakfast. . You can not take a pill in the morning to climb out of bed or in the evening after bedtime
treatment with alendronate should be supplemented with calcium and vitamin D.
The following side effects. Often (1/100, <1/10): From the digestive system : abdominal pain, dyspepsia, constipation, diarrhea, flatulence, oesophageal ulcer, dysphagia, bloating, heartburn. From the musculoskeletal system : ostalgiya, sustanon 250 reviews arthralgia, myalgia. nervous system : headache, irritability. not often (1/1000, <1/100): Common : pruritus, rash, flushing of the skin. From the digestive system : nausea, vomiting, gastritis, esophagitis, esophageal erosion, melena. Rarely (1/10000, <1/1000): Common : allergic reaction (hives, angiodema, Stevens-Johnson syndrome, toxic epidermal necrolysis); transient symptoms resembling acute phase reaction (myalgia, weakness, malaise, rare – high body temperature) most often develop in the beginning of treatment; rash; photosensitivity; hypocalcemia (often accompanied by predisposing factors). From the digestive system : narrowing of the esophagus, oropharyngeal ulcer, perforation of the upper gastrointestinal tract, ulcers, bleeding, however, the link with treatment is not always clear. From the senses : uveitis, scleritis. Laboratory findings : temporary, mild asymptomatic hypocalcemia and hypophosphatemia.
Signs of overdose. Hypocalcemia, hypophosphatemia, adverse reactions from the upper gastrointestinal tract (heartburn, esophagitis, gastritis, ulcer)
Specific treatment is not. Recommended reception of milk, antacids. To avoid irritation of the esophagus, do not induce vomiting, the patient should be placed in an upright position (sitting or standing).
INTERACTION WITH OTHER DRUGS
calcium, antacids, some oral medications, food, beverages, including mineral waters affect the absorption of alendronate; drugs can be taken orally is not earlier than 1 hour after taking alendronate.
Other, except for a change of absorbability, low probability of interaction.
ranitidine increases the bioavailability (the clinical significance is unknown). Nonsteroidal anti-inflammatory drugs increase the adverse effects of alendronate.
Special studies on drug interactions are not carried out, but alendronate studies involved patients at the same time taking other oral drugs. At the same time they have not observed adverse events associated with the simultaneous intake of other drugs.
Alendronate can cause local irritation of the digestive tract. Diseases of the upper flow of the trust may worsen during treatment with alendronate.
There are cases of adverse reactions on the part of the esophagus (esophagitis, esophageal ulcer or erosion), sometimes occurring in the form of severe, requiring hospital treatment, and is complicated by the formation of strictures. It is necessary to pay special attention to patients that if signs of irritation of the esophagus (dysphagia, chest pain when swallowing, new or worsening heartburn attacks), should stop taking the drug and consult a doctor. The risk of esophageal lesions was higher in patients who do not observe the rules of admission of the drug, or to continue treatment despite the appearance of signs of irritation of the esophagus. It is extremely important to promptly inform patients about the importance of compliance with the rules on the reception of the drug and make sure that the patient has understood this.
It should warn patients that if you skip the next dose, the missed tablet should be taken on the following morning; In no event should not take two tablets in one day.
The treatment can be started only after the elimination of hypocalcemia, disorders of mineral and vitamin exchanges (eg, vitamin deficiency D). Receiving Alendronate increases the content of mineral salts in the bone, the process may be accompanied by a change in asymptomatic calcium and phosphorus levels. Ensuring appropriate receiving calcium and vitamin D is especially important in the case of treatment of the patient glucocorticosteroid hormones.
Treatment should be combined with a diet enriched with calcium salts.
Effect of the drug on the ability to drive and use machinery
has no effect on ability to drive and perform tasks associated with a high risk of injury, but in the sustanon 250 reviews presence of adverse reactions from the body of driving and operating mechanisms are contraindicated until the complete disappearance of the adverse reactions. where to find anabolic steroids buy bac water uk where to buy steroid cream