- Hypersensitivity or intolerance to ofloxacin and other fluoroquinolone derivatives, quinolone. Deficiency of glucose-6-phosphate dehydrogenase. Tendon damage sustanon 250 cycle during the earlier treatment of quinolones.
- epilepsy (including history);
- decrease seizure threshold (including after a traumatic brain injury, stroke or a CNS inflammatory processes);
- age up to 18 years (not yet completed skeletal growth);
- creatinine clearance less than 20 mL / min.
Precautions : cerebral atherosclerosis, cerebrovascular accidents (in history), chronic renal failure, organic lesions of the central nervous system, lengthening of the QT interval on the ECG (including in history).
Dosing and Administration
The inside is not liquid, a small amount of water before or after meals. Doses are selected individually depending on the location and severity of the infection and the sensitivity of micro-organisms, the general condition of the patient, and liver and kidney function.
Adults – 200-600 mg per day, course of treatment – 7-10 days, the multiplicity of application -2 times day. In severe infections, or in treating overweight patients the daily dose may be increased to 800 mg.Dose to 400 mg per day may be administered in one administration, preferably in the morning. In gonorrhea – 400 mg once daily.
In patients with impaired renal function (when creatinine clearance 50-20 ml / min) daily dose should not exceed 200 mg for the multiplicity of reception 1-2 times a day. The maximum daily dose of liver failure -. 400 mg / day
Duration of treatment is determined by the sensitivity of the causative agent and the clinical picture. Treatment should continue for 2-3 days after the disappearance of symptoms and complete normalization of temperature. In the treatment of salmonellosis treatment – 7-8 days in uncomplicated urinary tract infections of the lower course of treatment – 3-5 days.
Side effect From sustanon 250 cycle the digestive system: gastralgia, anorexia, nausea, vomiting, diarrhea, flatulence, abdominal pain, increased activity of “liver” transaminases, hyperbilirubinemia, cholestatic jaundice, pseudomembranous enterocolitis. From the nervous system: headache, dizziness, lack of movement, tremors, convulsions, numbness and paresthesias of extremities, intense dreams, “nightmarish” dream, psychotic reactions, anxiety, state of arousal, phobias, depression, confusion, hallucinations, increased intracranial pressure. From the musculoskeletal system: tendinitis, myalgia, arthralgia , tenosynovitis, tendon rupture. From the senses: violation of color vision, diplopia, disturbances of taste, smell, hearing and balance. With the cardiovascular system: tachycardia, decreased blood pressure, lengthening the interval the QT. Allergic reactions: skin rash, itching, urticaria, hypersensitivity pneumonitis, allergic nephritis, eosinophilia, fever, angioedema, bronchoconstriction; erythema multiforme exudative (including Stevens-Johnson syndrome) and toxic epidermal necrolysis (Lyell’s syndrome), vasculitis, anaphylactic shock. For the skin: petechial hemorrhages (petechiae), bullous hemorrhagic dermatitis, papular rash with crusted showing the defeat of vessels (vasculitis). From the side of hematopoiesis: leukopenia, agranulocytosis, anemia, thrombocytopenia, pancytopenia, hemolytic and aplastic anemia. From the urinary system: acute interstitial nephritis, renal dysfunction, hypercreatininemia, elevated levels of urea. Other: goiter, superinfection , photosensitivity, hypoglycemia (in patients with diabetes), vaginitis.
Overdosing Symptoms: dizziness, confusion, lethargy, disorientation, drowsiness, and vomiting. Treatment: gastric lavage, symptomatic therapy. In hemodialysis removes 10-30% of the drug.
Interaction with other drugs
Reduces clearance theophylline by 25% (while the application should reduce the dose of theophylline).
cimetidine, furosemide, methotrexate and drugs that block kanaltsevuyu secretion, increase the concentration of ofloxacin in plasma.
Increases concentration of glibenclamide in plasma.
when concomitantly with vitamin K antagonists need to monitor coagulation blood system.
in the appointment of non-steroidal anti-inflammatory drugs, derivatives of nitroimidazole and methylxanthines increases the risk of neurotoxic effects.
When concomitant sustanon 250 cycle administration with corticosteroids increases the risk of tendon rupture, particularly in the elderly.
in the appointment of agents, alkalizing urine (carbonic anhydrase inhibitors, citrate, sodium bicarbonate ), increases the risk of crystalluria and nephrotoxic effects.
When coadministered with drugs that prolong the interval QT (IA and class III anti-arrhythmic drugs, tricyclic antidepressants, macrolides), increased risk of QT interval prolongation.
is not the drug of choice for pneumonia caused by pneumococcus. Not indicated in the treatment of acute tonsillitis.
In case of any side effects on the central nervous system, allergic reactions, pseudomembranous colitis requires removal of the drug. If pseudomembranous colitis, confirmed by colonoscopy and / or histologically demonstrated oral administration of vancomycin and metronidazole.
Rarely occurring tendinitis can lead to tendon rupture (predominantly Achilles tendon), particularly in elderly patients. In the event of signs of tendonitis, you should immediately discontinue treatment, to produce immobilization of the Achilles tendon and consult a podiatrist.
In applying the drug to women is not recommended to use tampons due to the increased risk of developing thrush.
The treatment possible worsening of myasthenia gravis, frequent attacks of porphyria in predisposed patients .
It may lead to false negative results when bacteriological diagnosis of tuberculosis (prevents the release of Mycobacterium tuberculosis).
It is not recommended to use more than 2 months, the period of treatment is exposed to sunlight, ultraviolet radiation (mercury-quartz lamp, solarium).
in patients with impaired hepatic function or kidneys necessary to monitor the plasma concentrations of ofloxacin. In severe renal and hepatic impairment increases the risk of toxic effects (dose adjustment is required).
In the period of sustanon 250 cycle treatment should refrain from activities that require high concentration and psychomotor speed reactions (transport driving, work with potentially dangerous machinery), alcohol intake. rexobol bodybuilding legs workout testosterone enanthate injection carb sources bodybuilding steroids for rheumatoid arthritis side effects are asthma inhalers steroids